Blood transfusions are today one of the commonest medical interventions and it is estimated that annually over 10 million units of blood are transfused in India. Apart from the ABO blood group systems there are a number of blood group systems now known encompassing a number of blood group antigens now known. While serology and genotyping can today identify a number of additional common antigens, it is impossible with the current state of the art technologies to identify all antigens. A rare blood group is defined as with a prevalence of less than 1 in 1000 individuals. The rare blood groups become important especially for people requiring chronic transfusions.
GUaRDIAN Transfusion Genomics Initiative
BGvar - a comprehensive resource for Blood Group Immunogenetics
BGvar is a comprehensive compilation of human blood group alleles belonging to International Society of Blood Transfusion (ISBT) approved human blood group systems. The resource integrates relevant data from a range of public sources, encompassing a total of 43 human group systems, 345 antigens, 1700 approved alleles. BGvar also enlists about 1706 blood group alleles predicted from 1000 Genomes Project and compiled from literature reports. The compiled variants are systematically annotated for their HGVS nomenclature, Global Allele Frequencies and corresponding clinical significance collated from literature evidences.